Testosterone-mediated regulation of renal GSTA1/2 expression in male mice.

ABSTRACT:

Importance

Glutathione S-transferases (GSTs) are detoxifying enzymes that protect cells from xenobiotics. In mouse kidneys, class α GST (GSTA) isoforms display sexually dimorphic expression, with males exhibiting lower levels.

Objective

This study investigates the effect of testosterone on renal GSTA isoform expression in male mice.

Methods

Renal expression of GSTA1/2, GSTA3, and GSTA4 was examined in orchiectomized mice with or without testosterone supplementation, as well as in intact mice treated with antiandrogens including bicalutamide and flutamide or exhibiting either high (HT) or low (LT) serum testosterone levels.

Results

Orchiectomy increased the expression of GSTA1/2, GSTA3, and GSTA4 at both the mRNA and protein levels, accompanied by elevate

SUBMITTER: Hwang H 

PROVIDER: S-EPMC12511890 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature