Ivermectin inhibits replication of porcine deltacoronavirus <i>in vitro</i>.

ABSTRACT:

Importance

Porcine deltacoronavirus (PDCoV) is an emerging swine enteric coronavirus that threatens the pig industry and acts as a viral spillover, infecting other farm animals and potentially humans. The recent emergence of highly pathogenic PDCoV in South Korea, causing severe neonatal piglet mortality, underscores the urgent need for effective countermeasures to mitigate economic and public health risks. Thus, discovering new therapeutic methods through drug repurposing is crucial for controlling PDCoV.

Objective

This study investigated ivermectin (IVM) for its antiviral effect on PDCoV in vitro and explored its mechanism of action.

Methods

The antiviral effects and mechanism of action of IVM against PDCoV were evaluated using various virological assays.

SUBMITTER: Lee D 

PROVIDER: S-EPMC12511896 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature