Effect of N-Butylscopolammonium Bromide and Metamizol Sodium on Heart Rate, Blood Pressure, and Echocardiographic Measurements in Warmblood Horses With Aortic and Mitral Valve Regurgitation.

ABSTRACT:

Background

Administration of N-butylscopolammonium bromide (NBB) with metamizol sodium (NBBM) causes tachycardia and hypertension, and has been associated with accentuated cardiac murmurs.

Objectives

To evaluate the effect of a pharmacological challenge using NBBM on valvular regurgitation and cardiac murmurs in horses with aortic (AR) and mitral valve regurgitation (MR).

Animals

Twenty Warmblood horses with AR and 20 with MR.

Methods

Cardiac auscultation and two-dimensional (2D), M-mode, color flow, pulsed wave Doppler flow, and tissue Doppler echocardiography were performed with simultaneous ECG recording and non-invasive blood pressure measurements during rest and pharmacological challenge using 0.2 mg/kg NBB and 25 mg/kg metamizol sodium. Cardiac dimensions

SUBMITTER: Dufourni A 

PROVIDER: S-EPMC12511949 | biostudies-literature | 2025 Nov-Dec

REPOSITORIES: biostudies-literature