Human Papillomavirus Vaccine immune responses in an Olive baboon model is not compromised by chronic <i>Schistosoma mansoni</i> infections.

ABSTRACT: Human papillomavirus (HPV) vaccines elicit specific serum antibodies that confer long-lasting protection and may reduce HPV-related cancers. However, helminthic infections such as chronic schistosomiasis infection at the time of HPV vaccination are known to alter immune responses. This study investigated the impact of chronic S. mansoni infection on immune responses to the HPV vaccine in olive baboons. Baboons were assigned to three groups: (1) untreated S. mansoni-infected, (2) S. mansoni-infected and treated with Praziquantel, and (3) uninfected controls. All received two doses of the Cervarix HPV vaccine four weeks apart. Immune responses were measured using flow cytometry and ELISA. Gardasil® quadrivalent HPV vaccine antigen was used in both ELISA and PBMC stimulat

SUBMITTER: Obiero L 

PROVIDER: S-EPMC12511963 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature