Clinical Significance of a Multicancer Screening Trial With Stage-Based End Points.

ABSTRACT:

Importance

The first randomized screening trial of a multicancer early detection test is ongoing, with the primary end point being the incidence of late-stage cancer. The unprecedented use of a stage-based end point and short 3-year follow-up raise questions about how results should be interpreted and used in developing multicancer screening policy.

Objective

To estimate outcomes of the trial and to identify information from the estimates that may aid in interpreting results of short-term trials evaluating multicancer screening tests.

Design, setting, and participants

This multicancer decision-analytic model estimated outcomes from registry data from the England National Cancer Registration and Analysis Service for cases diagnosed between January 2013 and December 201

SUBMITTER: Gogebakan KC 

PROVIDER: S-EPMC12511994 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature