Development of targeted drugs for diabetic retinopathy using Mendelian randomized pharmacogenomics.

ABSTRACT:

Purpose

This study aims to utilize genetic instrumental variables - protein quantitative trait loci (pQTL), and through analysis methods such as Mendelian randomization (MR), systematically screen and validate druggable proteins that have a causal relationship with diabetic retinopathy (DR), and further explore related drug targets, providing genetic evidence and new directions for the drug development of this disease.

Methods

The research was based on large-scale public databases to conduct two-sample Mendelian randomization (MR) analysis. Firstly, 511 encoded proteins were selected from the known 4,479 druggable genes as initial exposure factors, with the summary data of GWAS for diabetic retinopathy as the outcome. MR analysis was conducted using the inverse variance weig

SUBMITTER: Liu G 

PROVIDER: S-EPMC12512044 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature