Transcriptomic analysis reveals the key role of inflammatory and immune signaling in the anti-perimenopausal depression effects of Bushen Shugan Huayu decoction.

ABSTRACT:

Background

This study aims to explore the targets and signaling pathways significantly associated with perimenopausal depression through transcriptomics, as well as the potential intervention targets of the BSSGHY decoction.

Methods

Five patients diagnosed with perimenopausal depression in Beijing were treated with the BSSGHY decoction and clinically observed. The severity of depression and associated symptoms was assessed using the HAMD, Kupperman, and PSQI scales before and after treatment, and serum levels of inflammatory factors were quantified using ELISA. Differentially expressed genes in PBMCs were identified through mRNA sequencing and subsequently analyzed using DESeq2 software. Statistical analyses were performed using GraphPad Prism 10.0, and GO and KEGG enrichmen

SUBMITTER: Feng Z 

PROVIDER: S-EPMC12512047 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature