CLOX and neurotox: Utility of the clock drawing task in monitoring for immune effector cell-associated neurotoxicity syndrome following chimeric antigen receptor T-cell therapy.

ABSTRACT: Immune effector cell-associated neurotoxicity syndrome (ICANS)-associated cognitive impairment is common in patients who receive chimeric antigen receptor T-cell (CAR-T) therapy. This study evaluated the utility of the clock drawing task (CDT) in detecting ICANS in patients with haematological cancers following CAR-T therapy. Data were collected from CAR-T patients at The Alfred Hospital, Melbourne, Australia. Patients underwent frequent assessments using the immune effector cell-associated encephalopathy (ICE) score and the CDT, scored using a modified CLOX (CLOX-M) rating scale, during their admission. We retrospectively reviewed the medical records of consecutive patients who received CAR-T therapy between September 2022 and February 2024 to assess for ICANS and changes in ICE score and

SUBMITTER: Kazzi C 

PROVIDER: S-EPMC12512059 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature