CANA v1.0.0: efficient quantification of canalization in automata networks.

ABSTRACT:

Summary

The biomolecular networks underpinning cell function exhibit canalization, or the buffering of fluctuations required to function in a noisy environment. We present a new major release of CANA, v1.0.0, an open-source Python package for understanding canalization in automata network models, discrete dynamical systems in which activation of biomolecular entities (e.g. transcription of genes) is modeled as the activity of coupled automata. One understudied putative mechanism for canalization is the functional equivalence of biomolecular regulators (e.g. among the transcription factors for a gene). We study this mechanism using the theory of symmetry in discrete functions. We present a new exact method, schematodes, for finding maximal symmetry groups among the inputs to discret

SUBMITTER: Marcus AM 

PROVIDER: S-EPMC12512137 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature