Neurocognitive function in schizophrenia spectrum disorders: A 20-year prospective study of a community sample.

ABSTRACT: Longitudinal studies of neurocognition in schizophrenia spectrum disorders (SSD) usually follow relatively young first-episode patients across several years. Comparatively little is known about the neurocognitive trajectory of samples also consisting of older patients. This is a 20-year follow-up study of participants who performed the baseline assessment at different ages and utilizes data from the Swedish Clinical Long-Term Psychosis Study (CLIPS). At baseline, 61 SSD patients were included and available for clinical assessment after 20 years. Of these, 28 performed neurocognitive assessment at both baseline and 20 years later. The test results from this group were used for this study. After 20 years, the participants exhibited significantly worsening cognitive flexibility, verbal learni

SUBMITTER: Mohn C 

PROVIDER: S-EPMC12512163 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature