Isolation and genomic analysis of phage BUCT551 against drug-resistant <i>Aeromonas hydrophila</i>.

ABSTRACT: Aeromonas hydrophila (A. hydrophila) is a common pathogen in aquaculture that also causes opportunistic infections and sporadic food- and water-borne illness in humans. Phage therapy is increasingly considered a promising complementary medicine for antibiotic therapy. In this study, we isolated a novel A. hydrophila phage (designated BUCT551) using A. hydrophila strain Ah18 as an indicator. The one-step growth curve demonstrated that BUCT551 had a latent period of 20 min and a burst size of 32 PFU/cell at its optimal multiplicity of infection (0.1). BUCT551 had a survival pH range from 5 to 10 and could tolerant temperatures from 4 °C to 50 °C. Host range analysis showed that the phage was able to lyse not only A. hydrophila, but also Aeromonas veronii

SUBMITTER: Han P 

PROVIDER: S-EPMC12512217 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature