Role of Vitamin D Supplementation in Chronic Liver Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

ABSTRACT:

Context

Vitamin D deficiency is highly prevalent in chronic liver disease. Although international societies recommend vitamin D supplementation in cases of proven deficiency, the impact of vitamin D on chronic liver disease remains uncertain.

Objective

Our aim was to evaluate the effects of vitamin D supplementation in patients with chronic liver disease by conducting a systematic review and meta-analysis of randomized controlled trials (RCTs).

Data sources

We systematically searched PubMed, EMBASE and the Cochrane Library on July 2, 2024.

Data extraction

Our primary outcomes involved survival, controlled attenuation parameter (CAP), liver stiffness measurement (LSM), and effects on changes in liver enzymes. Secondary outcomes included lipid profile and homeost

SUBMITTER: Martinekova P 

PROVIDER: S-EPMC12512233 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature