Exploring the gut microbiota-Parkinson's disease link: preliminary insights from metagenomics and Mendelian randomization.

ABSTRACT:

Introduction

The relationship between the gut microbiome and Parkinson's disease (PD) has recently attracted significant attention, with most studies focused on analyzing microbial composition. However, our understanding of the potential causal relationship between the gut microbiota and PD remains limited.

Methods

We extracted microbiome data from the metagenome for broad taxonomic coverage and accurate functional analysis. Subsequently, Mendelian randomization was employed to elucidate the causal relationship between the gut microbiome and PD.

Results

The gut microbiota in PD patients was found to be systemically imbalanced, characterized by an abnormal enrichment of potential pathogenic bacteria, a significant reduction in key beneficial bacteria, and a reorganizat

SUBMITTER: Liu J 

PROVIDER: S-EPMC12512240 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature