Microbiota-based interventions for autism spectrum disorder: a systematic review of efficacy and clinical potential.

ABSTRACT:

Purpose

Autism spectrum disorder (ASD) is increasingly linked to gut microbiota imbalances, influencing both behavioral and gastrointestinal (GI) symptoms. This systematic review assesses the efficacy of microbiota-based interventions, including probiotics, prebiotics, synbiotics, and fecal microbiota transplantation (FMT), in improving ASD-related symptoms, aiming to provide insights into their therapeutic potential and inform future clinical applications.

Methods

A comprehensive systematic review was conducted following PRISMA guidelines and registered in PROSPERO (CRD42024615043). A structured literature search was performed in PubMed, Cochrane Library, and Scopus to identify peer-reviewed English-language studies. Eligible studies included randomized controlled trials (R

SUBMITTER: Taha H 

PROVIDER: S-EPMC12512243 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature