GYPC methylation performance in detecting cervical (pre)cancer in high-risk HPV-positive women using liquid-based cervical scrapes.

ABSTRACT:

Background

Methylation of host genes is promising for the triage of women with high-risk human papillomavirus (HR-HPV) infections. This study aimed to validate the potential value of Glycophorin C (GYPC) methylation (GYPC^m) in the early detection of cervical cancer.

Methods

We recruited HR-HPV-positive women at the hospital outpatient clinic between August and December 2023, using cytology triage. The remaining exfoliated cervical cells were subjected to GYPC^m testing. A total of 549 cases were finally included for analysis: 156 cervicitis, 303 cervical intraepithelial neoplasia (CIN)1, 49 CIN2, 37 CIN3, and 4 CC.

Results

The difference of GYPC^m ΔCp values between CIN1 and CIN2 was statistically significant in the pathology results of

SUBMITTER: Fan X 

PROVIDER: S-EPMC12512283 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature