Study protocol: feasibility and safety of conventional external-beam radiotherapy with an integrated stereotactic lite gross-tumour-volume boost for painful bone metastases: the HYBRID study.

ABSTRACT:

Background

Bone metastases cause significant pain and functional limitation. Conventional external beam radiotherapy (EBRT) provides effective symptom relief, but local progression remains frequent. Stereotactic body radiotherapy (SBRT) offers improved local control but is often resource-intensive and associated with higher vertebral compression fracture (VCF) rates. Integrating a simultaneous gross tumour volume (GTV) boost within a conventional EBRT regimen may provide a feasible and safe alternative.

Methods

This is a prospective, multicentre, multinational, single-arm study enrolling 100 adults with painful bone metastases from solid tumours. Eligible patients receive 20 Gy in 5 fractions with a 5 Gy "stereotactic-lite" GTV boost (total 25 Gy) or 30 Gy in 10 fractions wi

SUBMITTER: Lee SF 

PROVIDER: S-EPMC12512287 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature