Association between atherogenic index of plasma (AIP) and all-cause and cardiovascular mortality in patients with metabolic dysfunction-associated steatotic liver disease (MASLD): a cohort study based on NHANES 1999-2018.

ABSTRACT:

Background

Lipid metabolism plays a pivotal role in the pathogenesis of metabolic dysfunction-associated fatty liver disease (MASLD). However, the effect of the atherogenic index of plasma (AIP)-a novel biomarker for assessing lipid metabolic abnormalities and atherosclerosis risk-on MASLD-related mortality remains unclear.

Methods

This study included 6,567 patients with MASLD from the National Health and Nutrition Examination Survey (1999-2018), with mortality data linked to National Death Index records through 31 December 2019. Participants were categorised into quartiles based on AIP. The association between baseline AIP and all-cause mortality (ACM) or cardiovascular disease mortality (CVM) were investigated using multivariate Cox Models, with restricted cubic spline (RC

SUBMITTER: Gan M 

PROVIDER: S-EPMC12512302 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature