Melatonin alleviates oxidative stress induced damage in human iPSCs harboring mtDNA 3243A>G mutation via MAPK pathway.

ABSTRACT:

Background

Mitochondrial diseases are a group of serious inherited multisystem disorders caused by mutations in mitochondrial DNA (mtDNA) or nuclear DNA and still have faced a significant challenge to therapy due to their complicated genotype-phenotype relationships and diverse clinical manifestations. Human induced pluripotent stem cell (hiPSC) offered novel opportunities for cell-based modeling mitochondrial diseases in a patient-specific level. This study aims to explore possibility to potential strategy against mutation-associated oxidative damage through hiPSCs derived from mitochondrial diseases patients.

Methods

A human induced pluripotent stem cell line (mt-hiPSCs) from a patient harboring 70.70% heteroplasmic m.3243A>G mutation was established and exposed to hydroge

SUBMITTER: Pu Z 

PROVIDER: S-EPMC12512320 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature