Microbially Produced Imidazole Propionate Is Associated With Heart Failure and Mortality.

ABSTRACT:

Background

Over the past years, it has become clear that the microbial ecosystem in the gut has a profound capacity to interact with the host through the production of a wide range of bioactive metabolites. The microbially produced metabolite imidazole propionate (ImP) is clinically and mechanistically linked with insulin resistance and type 2 diabetes, but it is unclear how ImP is associated with heart failure.

Objectives

The authors aimed to explore whether ImP is associated with heart failure and mortality.

Methods

ImP serum measurements in 2 large and independent clinical cohorts of patients (European [n = 1,985] and North American [n = 2,155]) with a range of severity of cardiovascular disease including heart failure. Univariate and multivariate Cox regression an

SUBMITTER: Molinaro A 

PROVIDER: S-EPMC12512386 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature