Hybrid metallic nanozyme with nitric oxide-releasing photothermal coating for accelerated infected diabetic wound healing.

ABSTRACT: Infected diabetic wounds are prone to developing bacterial biofilms and are difficult to treat due to a lack of strategies that can eliminate drug-resistant bacteria. Conventional antibiotics can't achieve the desired antibacterial effect due to their limited penetration into the biofilm, which makes the treatment challenging. In this study, we developed NIR-responsive nitric oxide (NO) releasing Ce: Zn nanoflowers (PDA@SNP@Ce:Zn NFs) to combat the drug-resistant bacteria by the synergistic antibacterial effect of metal ions and photothermal effect. PDA@SNP@Ce:Zn NFs exhibited significant antibacterial and antibiofilm effects against Methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus (SA). The nanoflowers exhibited significant inhibitory effects on the virulence o

SUBMITTER: Padaga SG 

PROVIDER: S-EPMC12512412 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature