Decoding IBD progression: a dynamic biomarker atlas for personalized disease stratification.

ABSTRACT:

Background

Accurate staging is pivotal for tailoring treatment intensity, optimizing resource allocation, and improving long-term patient outcomes in IBD. The intestinal microbiota and transcriptional profiles emerge as critical determinants in IBD staging, demonstrating promise as non-invasive biomarkers for predicting disease progression and informing personalized therapeutic strategies.

Methods

We recruited 97 participants (IBD patients and healthy controls) at the First Affiliated Hospital of Chongqing Medical University, collecting fecal and serum samples for integrated multi-omics analysis. Microbial community profiling was performed via 16S rRNA sequencing, and host transcriptomic landscapes were characterized using RNA-seq. Stage-specific microbial signatures were id

SUBMITTER: Tao Y 

PROVIDER: S-EPMC12512421 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature