Distinct maternal DNA methylation associations with gestational age at early and late-mid term pregnancy in a low- and middle-income country: evaluation of biological, genetic, and psychosocial contributors.

ABSTRACT: Mothers undergo physiological and molecular changes over the course of gestation. These modifications "get under the skin" and may be reflected in the maternal epigenome through processes such as DNA methylation. Such an epigenetic mark may offer insights into maternal responses to prenatal influences and biological cues from the developing fetus, thereby functioning as an indirect indicator of the conditions the fetus experiences in utero. We measured whole blood DNA methylation using the MethylationEPIC BeadChip Infinium microarray v1.0 in 22 pregnant women from Pakistan, a low- and middle-income country (LMIC), at two timepoints during their term pregnancies (early: 10-19 weeks and late-mid: 22-29 weeks). We used DNA methylation profiles to predict immune cell proportions and tested dif

SUBMITTER: Jude MS 

PROVIDER: S-EPMC12512460 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature