Tryptophan metabolites and incident cardiovascular disease: The EPIC-Norfolk prospective population study.

ABSTRACT:

Background and aims

Cardiovascular disease (CVD) remains the largest cause of death globally due to various risk factors. One novel potential contributor to CVD might be the metabolism of the essential amino acid tryptophan (Trp), which through many pathways can produce immunomodulatory metabolites such as kynurenine, indole-3-propionate and serotonin. We aim to identify the metabolites with the strongest association with cardiovascular disease, utilizing a substantial and diverse cohort of individuals. In our pursuit of this aim, our primary focus is to validate and reinforce the findings from previous cross-sectional studies.

Methods

We used the community-based EPIC-Norfolk cohort (46.3 % men, age 59.8 ± 9.0) with a median follow-up of 22.1 (17.6-23.3) years to study assoc

SUBMITTER: Teunis CJ 

PROVIDER: S-EPMC12512466 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature