Transplantation of UC-MSCs in ovary improves ovarian function and intermediate outcomes in IVF/ICSI cycles of POI patients: a clinical cohort study.

ABSTRACT:

Background

This study aimed to evaluate the clinical outcomes of umbilical cord mesenchymal stem cell (UC-MSC) transplantation on ovarian function in women with premature ovarian insufficiency (POI), and its potential to improve in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) outcomes.

Methods

A clinical cohort study was conducted at the Reproductive Medicine Center of Nanjing Drum Tower Hospital from 2019 to 2023. The study included POI patients who underwent either UC-MSC ovarian tissue injection or traditional IVF/ICSI-FET treatment. UC-MSCs were isolated from Wharton's jelly of the umbilical cord, cultured, and transplanted into the ovaries of patients via transvaginal ultrasound-guided injection. The embryo freezing rate, number of oocytes retri

SUBMITTER: Huang C 

PROVIDER: S-EPMC12512470 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature