Atractylodin inhibits ferroptosis in sepsis‑induced acute gastrointestinal injury via SIRT3/PRDX3.

ABSTRACT: Gastrointestinal injury (GI) is a significant concern in various medical contexts, particularly in patients undergoing antiplatelet therapy, experiencing trauma, or dealing with the effects of medications. The present study investigated the effect of atractylodin, a bioactive compound derived from Atractylodes lancea (Thunb.) DC., traditionally used in medicinal applications. A sepsis animal model was established through cecal ligation and perforation. Mice were treated with atractylodin, with or without silencing of NAD‑dependent protein deacetylase sirtuin‑3 (SIRT3), via transfection with adeno‑associated virus (AAV) vectors. Atractylodin markedly improved mitochondrial function in vivo, as evidenced by increased mitochondrial‑related proteins via western blot analysis (TOM

SUBMITTER: Hu YX 

PROVIDER: S-EPMC12512527 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature