Geniposide alleviates kidney fibrosis by targeting STAT3-HK2-mediated glycolysis.

ABSTRACT:

Background

Geniposide (GP), which is extracted from the traditional Chinese herb Gardenia jasminoides, has extensive pharmacological effects. Recently, studies have shown its protective effects on kidney diseases. However, whether GP can alleviate unilateral ureteral obstruction (UUO)-induced renal interstitial fibrosis is unknown. In addition, its potential protective mechanism against kidney fibrosis is worthy of further study. We investigated the effect of GP on renal interstitial fibrosis induced by UUO in vivo and on HK-2 cells treated with transforming growth factor β1 (TGF-β1) in vitro and explored the underlying mechanisms involved.

Materials and methods

A UUO model was constructed, and the mice were treated with GP (50 mg/kg/day) for 10 days. The kidney injury score

SUBMITTER: Shi R 

PROVIDER: S-EPMC12512595 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature