P2RX4 promotes hepatocellular carcinoma progression via calcium-mediated PI3K/AKT activation and immune remodeling.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is frequently identified at advanced stages. This constrains therapeutic options and results in poor prognosis. P2RX4 is an ATP-gated ion channel that modulates calcium influx. It participates in cellular proliferation, inflammatory processes, and immunological reactions. Nonetheless, its role in HCC remains poorly comprehended. This study explored the expression, function, and immunological effects of P2RX4 in HCC.

Methods

We examined P2RX4 expression using TCGA-LIHC and TIMER2.0 databases. Protein levels were validated using immunohistochemistry in 140 HCC tissues. A prognostic model was developed utilising P2RX4 expression. In vitro investigations were conducted subsequent to the silencing of P2RX4. The experiments encompassed cel

SUBMITTER: Wang J 

PROVIDER: S-EPMC12512605 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature