Aztreonam intervention recalibrates microbial interactions between Pseudomonas aeruginosa and Streptococcus salivarius.

ABSTRACT:

Background

Polymicrobial infections are recognized as a direct cause of exacerbation in chronic respiratory infections. In patients with reduced lung function, the transfer of oral microbiota to the lungs is often higher than in healthy individuals. However, the mechanisms underlying the interaction between dominant pathogens and oral microbiota, as well as their relationship with antibiotics, remain poorly understood. Using Pseudomonas aeruginosa and Streptococcus salivarius, co-isolated from the bronchial fluid of chronic obstructive pulmonary disease (COPD) patients, as a model, we investigated their interspecies invasion dynamics under antibiotic intervention. This study employed a combination of phenotypic and transcriptomic analyses to elucidate interaction dynamics under ant

SUBMITTER: Gou S 

PROVIDER: S-EPMC12512625 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature