Identification and validation of feature genes of acute myocardial infarction based on ferroptosis-related genes.

ABSTRACT:

Background

Acute myocardial infarction (AMI) represents one of the most severe complications of coronary artery disease (CAD) and is a leading cause of mortality from noncommunicable diseases globally. In recent years, with the deepening of research on ferroptosis, the role of this cell death mode accompanied by iron accumulation and lipid peroxidation in myocardial infarction has been increasingly confirmed, which eventually leads to cell oxidative death. However, prognosis mechanism, and participation degree of ferroptosis in the occurrence of AMI still need to be further explored.

Methods

The gene expression data sets (GSE97320, GSE60993) of AMI patients and the control group were obtained from the Gene Expression Omnibus (GEO) data sets. Screening for ferroptosis-related

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC12512630 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature