Performance of the low-cost phenotypic thin-layer agar MDR/XDR-TB Colour Test (first generation, 1G, Color Plate Test) for identifying drug-resistant Mycobacterium tuberculosis isolates in a resource-limited setting.

ABSTRACT:

Background

The accessible, easy to use and timely, diagnosis of tuberculosis (TB) drug-susceptibility, is often challenging, particularly in resource-constrained settings. We therefore evaluated the phenotypic thin-layer agar based MDR/XDR-TB Colour Test, also known as the "First Generation (1G) Color Plate Test (TB-CX)" performance for detecting resistance of Mycobacterium tuberculosis (Mtb) isolates to selected anti-TB drugs versus other tests routinely used in our setting.

Methods

A cross-sectional study was conducted on Mtb clinical isolates stored at the Armauer Hansen Research Institute TB laboratory in Addis Ababa, Ethiopia. Drug-susceptibility testing was performed on 78 Mtb isolates for isoniazid, rifampicin, and moxifloxacin using the Colour Test and the Indirect P

SUBMITTER: Mebrat B 

PROVIDER: S-EPMC12512722 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature