Lattice radiation therapy for canine sinonasal carcinoma: feasibility study of spatially fractionated radiotherapy using volumetric modulated arc therapy.

ABSTRACT:

Background

Lattice radiotherapy (LRT) administers spatially fractionated doses to a tumor volume with the intent to induce beneficial anti-tumor host responses and avoid normal tissue damage. This study investigated feasibility of LRT for canine sinonasal carcinoma (SC) using volumetric modulated arc therapy (VMAT), aiming to achieve the following criteria: (1) place ≥ 3 vertices of high dose "peak" regions within the gross target volume (GTV) separated by low dose "valley" regions; (2) achieve a 3:1 and 5:1 peak-to-valley dose ratios (PVDR); (3) meet organ at risk (OAR) dose constraints; (4) meet quality assurance (QA) standards. A secondary aim was to assess the impact of dose calculation algorithms and grid size on dosimetry. The peak vertices were placed manually as 5 mm 3D sph

SUBMITTER: Gualtieri P 

PROVIDER: S-EPMC12512791 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature