Dietary index for gut microbiota and risk of incident irritable bowel syndrome: a large-scale prospective cohort study.

ABSTRACT:

Background

The novel Dietary Index for Gut Microbiota (DI-GM) quantifies dietary patterns influencing microbiota health, yet its association with irritable bowel syndrome (IBS) risk remains unexplored. We aim to investigate prospective association of DI-GM with incident IBS in a long-term cohort.

Methods

Participants free of IBS at baseline with at least one record of 24-hour dietary recall from UK Biobank were included (N = 175,103). DI-GM was composed of 14 food/nutrient components known to influence gut microbial health. Each component was scored 0 or 1 based on sex-specific median intakes, and total scores were summed. The primary outcome was incident IBS. Multivariable Cox models were used to estimate associated risk.

Results

Over a 12.56-years of follow-up, 2,98

SUBMITTER: Li Y 

PROVIDER: S-EPMC12512796 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature