Transcriptional analysis reveals a markedly reduced expression of the voltage-dependent calcium channel α2δ1 subunit in canine prostate cancer compared to benign prostatic hyperplasia.

ABSTRACT:

Background

Despite its low incidence, the aggressive nature and high metastatic potential of canine prostate cancer (PC) make it a serious problem in veterinary medicine. However, knowledge of the molecular mechanisms and regulatory networks underlying the development and progression of canine PC is still limited. Using high-throughput methods, many PC-related genes have been identified by comparing gene expression profiles in malignant and non-malignant prostate tissues. In these studies, the reference group containing both normal and hyperplastic prostate tissues specimens was compared to the group composed of cancerous tissues specimens. However, this approach does not allow the exclusion of inflammation-related genes from those directly involved in PC development and progressio

SUBMITTER: Zacharski M 

PROVIDER: S-EPMC12512813 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature