Neutrophil activation in juvenile dermatomyositis: associations with muscle function and disease progression.

ABSTRACT:

Background

Juvenile dermatomyositis (JDM) is an inflammatory vasculopathy characterized by muscle weakness and systemic inflammation. This study aimed to investigate the clinical utility of neutrophil activation markers, specifically calprotectin (S100A8/A9) and myeloperoxidase (MPO)-DNA complexes, as potential biomarkers for muscle inflammation and predictors of muscle outcomes in JDM.

Findings

Plasma levels of calprotectin and MPO-DNA were quantified using ELISA in JDM (n = 36), juvenile idiopathic arthritis (JIA, n = 13), and healthy controls (HCs, n = 21). Disease severity and muscle function were assessed using the Childhood Myositis Assessment Scale (CMAS), Physician Global Assessment (PGA), and Manual Muscle Testing 8 (MMT8). JDM patients exhibited significantly highe

SUBMITTER: Shi J 

PROVIDER: S-EPMC12512863 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature