Pancreatic Damage in Ovarian Cancer-Associated Cachexia Is Driven by Activin A Signalling.

ABSTRACT:

Background

Cancer-associated cachexia (CAC) is a severe metabolic disorder characterized by involuntary weight loss, skeletal muscle atrophy and adipose tissue depletion. It is a major contributor to morbidity and mortality in the advanced stages of various cancers. However, the impact of CAC on the pancreas remains largely unexplored.

Methods

We used mice with constitutively active PI3K in oocytes, generated through a Cre-inducible Pik3ca* knock-in allele driven by Gdf9-icre and performed histological and molecular analyses of the pancreas during cachexia development. Additionally, we examined pancreatic changes following ovariectomy and administration of Follistatin 288 (FST288).

Results

Mice that developed cachexia symptoms associated with granulosa cell tumour (GC

SUBMITTER: Abazarikia A 

PROVIDER: S-EPMC12512902 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature