Distinct lung microbiota community states are associated with pulmonary nontuberculous mycobacterial disease prognosis.

ABSTRACT:

Background

The incidence of nontuberculous mycobacterial pulmonary disease (PNTM) is rising, but the available treatments have limitations. Currently, the understanding of the ecology of the airway microbiota in PNTM is limited, especially regarding community structure, dynamics, and their relationship with clinical outcomes.

Methods

We used metagenomic sequencing to characterize the lung microbiota in bronchoalveolar lavage fluid (BALF). We evaluated the prognosis of patients with PNTM through respiratory specimen cultures and chest CT scans.

Results

PNTM exhibit distinct airway microbiota characteristics compared to controls, however, no significant differences were observed in NTM species. A Dirichlet multinomial mixture model was used to identify two distinct comm

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12512908 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature