Comparison of thalamic atlases and segmentation techniques in defining motor and sensory nuclei for deep brain stimulation targeting in essential tremor.

ABSTRACT:

Introduction

Many thalamic atlases are available for deep brain stimulation (DBS) applications, but their usage and clinical validation vary. This study investigated the effectiveness of six atlases in DBS targeting for essential tremor (ET) through structural differences, impact of two thalamic segmentation methods, and correspondence with clinical outcomes via individualized tissue activation modeling.

Methods

22 ET patients with unilateral VIM DBS were retrospectively analyzed. Volume of tissue activation (VTA) models were linked to tremor reduction (n = 22) and sustained paresthesia (n = 32). Six atlases were co-registered for pairwise comparison. Patient thalami were segmented using atlas-based segmentation (ABS) and diffusion tensor imaging-based segmentation (DTIBS).

SUBMITTER: Zilberman ME 

PROVIDER: S-EPMC12512978 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature