The association between insulin resistance assessed by estimated glucose disposal rate and stroke prevalence and mortality in non-diabetic people: evidence from two prospective cohorts.

ABSTRACT:

Background

The estimated glucose disposal rate (eGDR), serving as a measure of insulin resistance (IR), provides a simpler and more accessible method for assessing insulin sensitivity. However, its association with stroke and mortality in non-diabetic patients remains to be fully clarified.

Methods

Data from the National Health and Nutrition Examination Survey (NHANES) Study (2003-2014, n = 11,063, age ≥ 45) were examined. Participants with diabetes, coronary heart disease (CHD), or missing key data were excluded. eGDR was calculated based on waist circumference, hypertension status, and glycated hemoglobin (HbA1c). The primary outcomes were stroke prevalence and all-cause, cardiovascular, and cerebrovascular disease mortality. For stroke outcomes, a cross-sectional analysis

SUBMITTER: Li D 

PROVIDER: S-EPMC12512985 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature