Epigenetic and transcriptomic analysis revealed ceRNA regulatory network in glioblastoma multiforme.

ABSTRACT: Glioblastoma multiforme (GBM) is one of the most common cancers among malignant tumors, and extensive evidence suggests that the prognosis of various human cancers is associated with DNA methylation. Therefore, we analyzed potential GBM prognostic biomarkers by combining GBM methylation sequencing data and transcriptome sequencing data. Biostatistical analysis of the expression of three RNA types (long non-coding RNA, microRNA, and mRNA) from The Cancer Genome Atlas (TCGA) was performed to determine the correlation between NACAD and GBM prognosis. Additionally, we predicted and validated a competitive endogenous RNA (ceRNA) regulatory network associated with epigenetic DNA methylation modifications. The ceRNA regulatory network (DCTN1-AS1-hsa-let-7a-5p-NACAD) was found to be related to ove

SUBMITTER: Li Z 

PROVIDER: S-EPMC12513008 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature