Selenium supplementation for management of gestational diabetes mellitus in pregnancy: a systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Selenium is thought to improve glucose and lipid metabolism in pregnant women with gestational diabetes mellitus. However, this finding is somewhat controversial. In this paper, we evaluated the effects of selenium supplementation on glucose and lipid metabolism in patients with GDM.

Methods

Searches were carried out in PubMed, Cochrane Library, Web of Science, EMBASE, CBM, Chinese National Knowledge Infrastructure, Wan Fang, and VIP from their inception until May 2025. Two reviewers independently extracted data. The Cochrane risk of bias tool was applied to assess the methodological quality of every study and Meta-analysis was carried out with a random effects model or a fixed effects model. Publication bias was evaluated by the Begg and Egger tests.

Results</

SUBMITTER: Sun J 

PROVIDER: S-EPMC12513009 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature