Subregional amygdala functional connectivity abnormalities and anhedonia impairments in first-episode schizophrenia.

ABSTRACT:

Background

Although abnormal amygdala functional connectivity (FC) has been reported in schizophrenia, most studies have treated the amygdala as a single structure. This study aimed to explore the association between amygdala subregional FC and anhedonia in patients with first-episode schizophrenia (FES).

Methods

Resting-state functional magnetic resonance imaging (fMRI) was conducted in 31 FES patients (including 11 drug-naïve) and 33 matched healthy controls (HCs). Clinical symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS), and anhedonia was evaluated via the Snaith-Hamilton Pleasure Scale (SHAPS). Whole-brain FC analyses of amygdala subregions were performed, followed by group comparisons and correlation analyses with anhedonia scores.

Resul

SUBMITTER: Kuang Q 

PROVIDER: S-EPMC12513012 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature