Transcriptomic analysis demonstrates moderators of muscle quality are altered in age-related sarcopenic obesity.

ABSTRACT:

Background

Sarcopenic obesity (SO) is the combined condition of sarcopenia and obesity, which commonly occurs in the older adult population. SO is associated with poor physical function, increased risk of musculoskeletal injury, and reduced quality of life and independence. Information on the molecular underpinnings of this condition is limited. The aim of this study was to provide a transcriptomic analysis characterizing SO induced by lifelong obesity and to provide a deeper understanding of the etiology of the condition.

Results

Young (Y) (6 mo) and aged (A) (21-24 mo) mice were fed either normal chow (L) (12% kcal from fat) or high-fat (O) (60% kcal from fat) diets ad libitum. Through multiple analyses, we observed that genes related to ECM remodeling were downregulated i

SUBMITTER: Schrems ER 

PROVIDER: S-EPMC12513022 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature