Sex-related differences in myocardial fibrosis among patients with aortic stenosis: A systematic review and meta-analysis.

ABSTRACT:

Background

Aortic stenosis (AS) leads to pathological myocardial remodeling, particularly fibrosis, which contributes to adverse outcomes including heart failure, arrhythmias, and mortality. Evidence suggests sex-specific differences in fibrotic response, but individual studies are underpowered for definitive conclusions. This meta-analysis aimed to evaluate sex-related differences in myocardial fibrosis using cardiac magnetic resonance (CMR) parameters.

Methods

Three databases were searched for studies comparing male and female patients with AS reporting CMR-derived measures. The primary outcomes were late gadolinium enhancement (LGE%), infarct-related and non-infarct-related LGE, extracellular volume (ECV) and Septal E/e'. Effect sizes were expressed as risk ratios

SUBMITTER: Onyeji PC 

PROVIDER: S-EPMC12513023 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature