Long-term Follow-up After Hypothermic Oxygenated Machine Perfusion in DCD Liver Transplantation: Results of a Randomized Controlled Multicenter Trial (DHOPE-DCD).

ABSTRACT:

Background and aim

Transplantation of livers from donation after circulatory death (DCD) donors is associated with an increased risk of nonanastomotic biliary strictures (NAS). Dual hypothermic oxygenated machine perfusion (DHOPE) of donor livers before transplantation has been shown to reduce the incidence of symptomatic NAS and acute cellular rejection (ACR) within 6 months, but long-term results are unknown. The aim of this study was to assess the 5-year incidence of NAS and ACR in the DHOPE-DCD Trial (ClinicalTrials.gov number NCT02584283).

Methods

Between January 2016 and July 2019 recipients of DCD livers in 6 European centers were randomly assigned to receive that liver either after DHOPE (machine perfusion group) or after conventional static cold storage (control gro

SUBMITTER: van Rijn R 

PROVIDER: S-EPMC12513034 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature