Effect of Urine-guided Intraoperative Hydration on Incidence of Acute Kidney Injury after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Pseudomyxoma Peritonei: A Randomized Trial.

ABSTRACT:

Background

Acute kidney injury (AKI) is common after cytoreductive surgery (CRS) and hyperthermia intraperitoneal chemotherapy (HIPEC). Urine-guided hydration is found effective in preventing AKI in other high-risk patient populations. This study tested whether targeted intraoperative urine output maintenance and simultaneous hydration can reduce AKI in patients after CRS-HIPEC.

Methods

In this randomized trial, adult patients who were scheduled to undergo CRS and cisplatin-based HIPEC for pseudomyxoma peritonei were randomized to receive either urine-guided hydration (urine output greater than or equal to 3 ml ⋅ kg -1 ⋅ h -1 or greater than or equal to 200 ml ⋅ h -1 ) or routine hydration (urine output greater than or equal to 0.5 ml ⋅ kg -1 ⋅ h -1 ) during the procedure. T

SUBMITTER: Gao SC 

PROVIDER: S-EPMC12513041 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature