Leveraging dixon-based magnetic resonance imaging for pelvic bone marrow imaging in radiotherapy.

ABSTRACT:

Background and purpose

Pelvic radiotherapy-induced bone marrow (BM) damage adversely affects patient prognosis. Progress in BM-sparing radiotherapy is limited by the lack of standardized BM quantification and the inherent constraints of magnetic resonance spectroscopy (MRS), the current gold standard for BM magnetic resonance imaging (MRI). Proton density fat fraction (PDFF), derived from DIXON-based MRI, has emerged as an imaging biomarker for detecting BM changes. This study evaluated the potential of DIXON-based MRI in pelvic BM for radiotherapy.

Materials and methods

Three existing DIXON-based techniques were optimized and compared to establish clinical protocols. In vitro measurements were performed using fat phantoms calibrated against thermogravimetric analysis

SUBMITTER: Wang C 

PROVIDER: S-EPMC12513058 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature