Regulating microbubble clusters for improving temporal uniformity of stable cavitation intensity under rapid short-pulse ultrasound.

ABSTRACT: Stable cavitation induced by rapid short-pulse (RaSP) ultrasound produces more uniform bioeffects in the treatment region than traditional long-pulse sequences. However, temporal non-uniformity of stable cavitation intensity (SCI)-either within a single RaSP or across multiple RaSPs-compromises the efficiency and biosafety of cavitation-based therapies. This study investigates the causes of temporal non-uniformity in SCI and proposes strategies to enhance uniformity. Monodisperse microbubbles, that were generated using a flow-focusing microfluidic device, were exposed to a single RaSP (frequency: 1 MHz; pulse repetition frequency: 1 kHz; peak negative pressure (PNP): 150-250 kPa; pulse length (PL): 20-150 μs; total number of pulses: 100) in a polydimethylsiloxane-gel flowing phantom. Synch

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC12513081 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature