Antagonistic histone post-translational modifications improve the fidelity of epigenetic inheritance - a Bayesian perspective.

ABSTRACT:

Background

Histone Post-Translational Modifications (PTMs) are important epigenetic marks, whose specific pattern over the chromatin plays a critical role in turning the corresponding gene on/off. During DNA replication in mitotic cells, the histone PTMs are dislodged from the mother chromatid, ahead of the replication fork, and distributed uniformly at random among the daughter chromatids. We show that maintaining the fidelity of a primary PTM pattern, from the partial information available after replication, can be significantly improved by the presence of an additional antagonistic PTM sequence in the mother.

Results

Building on our previous study which proposed mechanisms for maintaining fidelity by utilizing only half the parental nucleosomes, the current work considers

SUBMITTER: Prabhu BNB 

PROVIDER: S-EPMC12513102 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature