The combined prognostic effect of the triglyceride-glucose index and estimated glucose disposal rate on long-term mortality among individuals with cardiovascular-kidney-metabolic syndrome stages 0-3.

ABSTRACT:

Background

Previous studies have demonstrated that the triglyceride-glucose (TyG) index in combination with the estimated glucose disposal rate (eGDR) could predict mortality risks in the normal population. Our studies have focused on their additive effects on patients with cardiovascular-kidney metabolic syndrome (CKM) syndrome stages 0-3.

Methods

Participants were sourced from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018. The restricted cubic spline (RCS) curves modeled the associations between the TyG index, eGDR, and mortality. Cox proportional regression models, Kaplan-Meier (KM) curve and subgroup analysis were performed to investigate the combined association. Machine learning was used in the development of predictive models.

Resu

SUBMITTER: Wang K 

PROVIDER: S-EPMC12513125 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature