Thyroid disease and breast cancer, benign breast neoplasm: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Breast cancer (BC) is a prevalent and significant health issue and a major contributor to global cancer incidence, accounting for 31% of all reported cases in women. Benign breast neoplasm, as a benign tumor with a high incidence in women, may play an important role in the development of BC. Previous studies have shown that thyroid dysfunction and thyroid cancer (TC) can lead to the occurrence of many cancers. Therefore, we conduct Mendelian randomization (MR) analysis to explore the causality of thyroid dysfunctions, TC, and breast neoplasm.

Methods

The data of the analysis from the genome-wide association study (GWAS) dataset. The exposure includes FT4, TSH, hypothyroidism, hyperthyroidism, and TC. Meanwhile, the outcome consists of BC, HER2-enriched BC, HER2-ne

SUBMITTER: Wang B 

PROVIDER: S-EPMC12513146 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature